Company Names, addresses, dates:
  R.E. Wiley & Co, North Main Street, Neapolis VA
  R.R. Wiley, 636 North Main Steet, Danville VA
  R.E. Wiley & Co, Danville VA

Notes:
R.E. Wiley's Drug Store was located on North Main Street in Neapolis, near the Main Street Bridge. For a short time, North Danville was called Neapolis¹.
R.R. Wiley (maybe type for R.E.?) was located at 636 North Main Street in 1902¹

Bottles:

(enlarge)

Clear 4.5" bottle embossed: horizontal: 3ii vertical: R.E. WILEY & CO. / DRUGGISTS / DANVILLE, VA. bottom: W.T.CO. / A / U.S.A.